Transcriptomics-Based Subphenotyping of the Human Placenta Enabled by Weighted Correlation Network Analysis in Early-Onset Preeclampsia With and Without Fetal Growth Restriction.

William E Ackerman IvCatalin S BuhimschiThomas L BrownGuomao ZhaoTaryn L SummerfieldIrina Alexandra Buhimschi

Published in: Hypertension (Dallas, Tex. : 1979) (2023)

We provide novel evidence for a molecular subphenotype consistent with a glycolytic metabolic shift that occurs more frequently but not universally in placental specimens of EOPE±FGR.

Keyphrases

early onset
network analysis
late onset
endothelial cells
single cell
induced pluripotent stem cells
pluripotent stem cells
pregnant women
magnetic resonance
single molecule
computed tomography