IL-1β + TGF-β2 dual-licensed mesenchymal stem cells have reduced major histocompatibility class I expression and positively modulate tenocyte migration, metabolism, and gene expression.

Drew W KochAnna FronebergerAlix BerglundShannon ConnardAlexis SoutherLauren V Schnabel

Published in: Journal of the American Veterinary Medical Association (2024)

Our data indicate that conditioned media containing paracrine factors secreted from dual-licensed MSCs significantly modulates in vitro tenocyte function, which may confer benefits in vivo to healing tendons following injury. Additionally, due to reduced MHC class I expression in dual-licensed MSCs, this technique may also provide an avenue to provide an effective "off-the-shelf" allogenic source of MSCs.

Keyphrases

mesenchymal stem cells
umbilical cord
gene expression
poor prognosis
bone marrow
dna methylation
binding protein
cell therapy
transforming growth factor
big data
machine learning
signaling pathway
artificial intelligence
epithelial mesenchymal transition