Expectation reshapes V4 neuronal activity and improves perceptual performance.

Recent visual experience creates expectations that heavily influence our visual perception. How does expectation shape the activity of cortical neurons to allow for improved perceptual discrimination of visual inputs? We recorded from populations of neurons in visual cortical area V4 while monkeys performed a natural image change detection task under different expectation conditions. We found that higher expectation led to an improvement in the ability to detect a change in an image. This improvement was associated with decreased neural responses to the image, providing evidence that a reduction in activity can improve stimulus encoding. The decrease in response could not be fully explained by short-timescale adaptation, suggesting partially separate mechanisms of adaptation and expectation. Additionally, higher expectation was associated with decreased trial-to-trial shared variability, indicating that a reduction in variability is a key means by which expectation influences perception. Taken together, the results of our study contribute to an understanding of how visual experience and expectation can shape our perception and behavior through modulating activity patterns across the visual cortex.