Interleukin-1β and cathepsin D modulate formation of the terminal complement complex in cultured human disc tissue.
Graciosa Q TeixeiraZhiyao YongAmelie KuhnJana RieggerRaquel M GoncalvesMichael RufUwe M MauerMarkus Huber-LangAnita IgnatiusRolf E BrennerCornelia Neidlinger-WilkePublished in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2021)
These results suggest a functional relevance of IL-1β and CTSD in modulating TCC formation in DD, with differences between tissue regions. Although strong TCC deposition may represent a degeneration-associated event, IL-1β may inhibit it. In contrast, TCC formation was shown to be triggered by CTSD, indicating a multifunctional involvement in disc pathophysiology.