Preclinical mouse model of a misfolded PNLIP variant develops chronic pancreatitis.

Guoying ZhuSteven J WilhelmLeah G GeorgeBrett M CassidySammy ZinoCliff J LukeMina HannaStephen StoneNhung PhanNeel MatiwalaSamuel J BallentineMark E LoweXunjun Xiao

Published in: Gut (2023)

Expression of PNLIP p.T221M in a preclinical mouse model results in CP caused by ER stress and proteotoxicity of misfolded mutant PNLIP.

Keyphrases

mouse model
poor prognosis
cell therapy
stem cells
wild type
bone marrow