CuH-Catalyzed Asymmetric 1,6-Conjugate Reduction of p-Quinone Methides: Enantioselective Synthesis of Triarylmethanes and 1,1,2-Triarylethanes.
Ting PanPan ShiBo ChenDa-Gang ZhouYa-Li ZengWen-Dao ChuLong HeQuan-Zhong LiuChun-An FanPublished in: Organic letters (2019)
The first copper hydride (CuH)-catalyzed asymmetric 1,6-conjugate reduction of p-quinone methides is reported. This protocol provides a new method to access a variety of triarylmethanes and 1,1,2-triarylethanes in good yields with excellent enantioselectivities and broad functional group tolerance.