The Role of the Non-Steroidal Mineralocorticoid Antagonist Finerenone in Cardiorenal Management.
Craig J BeaversPublished in: Current cardiology reports (2022)
The recently published phase III FIDELIO-DKD and FIGARO-DKD, alone and pooled, in patients with CKD and diabetes demonstrate that finerenone reduces the composite of CV death, non-fatal myocardial infarction, nonfatal stroke, and hospitalization for heart failure (HF) with hospitalization for HF being the primary driver of this composite. Finerenone is indicated to reduce renal and CV outcomes in patients with CKD and diabetes. Future investigations of this agent include patients with non-diabetic CKD, HF with preserved ejection fraction, and with the use of sodium-glucose transporter type 2 inhibitors.
Keyphrases
- phase iii
- ejection fraction
- heart failure
- acute heart failure
- chronic kidney disease
- type diabetes
- glycemic control
- open label
- aortic stenosis
- clinical trial
- cardiovascular disease
- atrial fibrillation
- left ventricular
- double blind
- phase ii
- placebo controlled
- anti inflammatory drugs
- randomized controlled trial
- insulin resistance
- skeletal muscle
- metabolic syndrome
- blood brain barrier
- study protocol
- weight loss