Calcium Intake and Iron Status in Human Studies: A Systematic Review and Dose-Response Meta-Analysis of Randomized Trials and Crossover Studies.
Ajibola Ibraheem AbioyeTaofik A OkuneyeAbdul-Majeed O OdesanyaOlufunmilola AdisaAsanat I AbioyeAyorinde I SoipeKamal A IsmailJaeWon F YangLuther-King FasehunMoshood O OmotayoPublished in: The Journal of nutrition (2021)
The existing body of studies is insufficient to make recommendations with high confidence due to heterogeneity in designs, limitations of ferritin as an iron biomarker, and a lack of intake studies in pregnant women. Prescribing separation of prenatal calcium and iron supplements in free-living individuals is unlikely to affect the anemia burden. There is a need for effectiveness trials comparing the effects of prescribing separated intake to concurrent intake, with functional endpoints as primary outcomes and adherence to each supplement as intermediate outcomes.
Keyphrases
- case control
- pregnant women
- iron deficiency
- systematic review
- primary care
- randomized controlled trial
- endothelial cells
- chronic kidney disease
- type diabetes
- clinical trial
- emergency department
- adipose tissue
- squamous cell carcinoma
- metabolic syndrome
- meta analyses
- mass spectrometry
- induced pluripotent stem cells
- insulin resistance
- liquid chromatography
- clinical practice