The Voices of Stakeholders Involved in Precision Medicine: The Co-Design and Evaluation of Qualitative Indicators of Intervention Acceptability, Fidelity and Context in PRecISion Medicine for Children With Cancer in Australia.
James SmithJeffrey BraithwaiteTracey A O'BrienStephanie SmithVanessa J TyrrellEmily V A MouldJanet C LongFrances RapportPublished in: Qualitative health research (2022)
We report a novel approach of amalgamating implementation outcomes of acceptability and fidelity alongside context as a new way of qualitatively evaluating implementation outcomes and context of a precision medicine intervention. A rapid qualitative online proforma was co-designed with stakeholders and sent to a purposive sample of healthcare professionals involved in an early-phase clinical trial intervention. Data were analysed using Framework Analysis. A total of 24 out of 68 proformas were returned. Although some participants raised concerns about drug medication access issues, the main intervention was well accepted and understood across professional groups. Comprehension was enhanced through exposure to specialist multidisciplinary meeting arrangements. In conclusion, a rapid data collection tool and framework are now available to assess readily measurable, qualitative indicators of acceptability, fidelity of receipt and contextual fit within the dynamic precision medicine context.
Keyphrases
- randomized controlled trial
- clinical trial
- healthcare
- primary care
- systematic review
- electronic health record
- quality improvement
- palliative care
- young adults
- emergency department
- social media
- papillary thyroid
- adverse drug
- squamous cell carcinoma
- type diabetes
- metabolic syndrome
- adipose tissue
- machine learning
- phase ii
- double blind
- artificial intelligence
- deep learning
- drug induced