Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients.
Tina SarénMohanraj RamachandranGustav GammelgårdTanja LövgrenClaudio MirabelloÅsa K BjörklundKristina WikströmJamileh HashemiEva FreyhultHåkan AhlströmRose-Marie AminiHans HagbergAngelica LoskogGunilla EnbladMagnus EssandPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
We identified cell-intrinsic characteristics of effector CD8+CAR-Ts correlating with response that could be used as an indicator for clinical outcome. The results in the study also serves as a guide to CAR-T manufacturing practices.
Keyphrases
- single cell
- phase ii study
- rna seq
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- induced apoptosis
- primary care
- healthcare
- open label
- locally advanced
- peritoneal dialysis
- randomized controlled trial
- prognostic factors
- squamous cell carcinoma
- diffuse large b cell lymphoma
- dendritic cells
- clinical trial
- oxidative stress
- patient reported outcomes
- bone marrow
- cell proliferation
- patient reported
- type iii