Copy number variation of IL17RA gene and its association with the ankylosing spondylitis risk in Iranian patients: a case-control study.
Hamideh AghaeiElham FarhadiMaryam AkhtariSara ShahbaShayan MostafaeiAhmadreza JamshidiShiva PoursaniMahdi MahmoudiMohammad Hossein NicknamPublished in: BMC medical genetics (2020)
Our findings revealed that a low copy number of IL17RA might confer a susceptibility risk to AS. However, it is probably not directly involved in the regulation of IL17RA mRNA expression. Epigenetic mechanisms like DNA methylation, post-transcriptional, and -translational modifications that regulate the expression of the genes may contribute in upregulation of IL17RA mRNA expression in the loss of gene copy number condition.
Keyphrases
- copy number
- ankylosing spondylitis
- dna methylation
- genome wide
- mitochondrial dna
- rheumatoid arthritis
- disease activity
- gene expression
- poor prognosis
- end stage renal disease
- systemic lupus erythematosus
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- transcription factor
- binding protein
- oxidative stress
- heat stress
- patient reported
- breast cancer risk