Gene therapy with phosphodiesterases 2A and 4B ameliorates heart failure and arrhythmias by improving subcellular cAMP compartmentation.

Nikoleta PavlakiAlexander FroeseWener LiKirstie A De JongBirgit GeertzHariharan SubramanianSanika MohagaonkarXiaojing LuoMario SchubertRobert WiegmannJean Piero MargariaAlessandra GhigoSusanne KämmererEmilio HirschAli El-ArmoucheKaomei Guan Viacheslav O Nikolaev

Published in: Cardiovascular research (2024)

Our data indicate that gene therapy with phosphodiesterases can prevent HF including associated cardiac remodelling and arrhythmias by restoring altered cAMP compartmentation in functionally relevant subcellular microdomains.

Keyphrases

gene therapy
heart failure
left ventricular
congenital heart disease
binding protein
acute heart failure
electronic health record
protein kinase
big data
cardiac resynchronization therapy
atrial fibrillation
machine learning
data analysis