Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy.
Kavita GaurAlexandra M Vázquez-SalgadoGeraldo Duran-CamachoIrivette Dominguez-MartinezJosué A Benjamín-RiveraLauren Fernández-VegaLesly Carmona SarabiaAngelys Cruz GarcíaFelipe Pérez-DelizJosé A Méndez RománMelissa Vega-CartagenaSergio A Loza-RosasXaymara Rodriguez AcevedoArthur D TinocoPublished in: Inorganics (2018)
A very promising direction in the development of anticancer drugs is inhibiting the molecular pathways that keep cancer cells alive and able to metastasize. Copper and iron are two essential metals that play significant roles in the rapid proliferation of cancer cells and several chelators have been studied to suppress the bioavailability of these metals in the cells. This review discusses the major contributions that Cu and Fe play in the progression and spreading of cancer and evaluates select Cu and Fe chelators that demonstrate great promise as anticancer drugs. Efforts to improve the cellular delivery, efficacy, and tumor responsiveness of these chelators are also presented including a transmetallation strategy for dual targeting of Cu and Fe. To elucidate the effectiveness and specificity of Cu and Fe chelators for treating cancer, analytical tools are described for measuring Cu and Fe levels and for tracking the metals in cells, tissue, and the body.
Keyphrases
- aqueous solution
- metal organic framework
- induced apoptosis
- papillary thyroid
- signaling pathway
- cell cycle arrest
- human health
- health risk
- squamous cell
- randomized controlled trial
- systematic review
- health risk assessment
- drug induced
- emergency department
- endoplasmic reticulum stress
- squamous cell carcinoma
- deep learning
- cell death
- cell proliferation
- pi k akt
- big data
- mass spectrometry
- quality improvement
- drug delivery
- drinking water
- solid state
- sensitive detection
- electronic health record
- loop mediated isothermal amplification