Pharmacodynamic and immunological interactions of amphotericin B formulations and voriconazole with human neutrophils against mature Scedosporium apiospermum and Fusarium spp. biofilms.
Katerina VikeloudaMaria SimitsopoulouCharalampos AntachopoulosLemonia SkouraEmmanuel RoilidesPublished in: The Journal of antimicrobial chemotherapy (2023)
The synergistic, additive or antagonistic effects of DAmB, LAmB or voriconazole on biofilm-exposed PMNs are organism-specific, with FSSC exhibiting greater resilience than S. apiospermum to antifungals. Biofilms of both moulds caused dampened immune responses. The drug-mediated immunomodulating effect on PMNs, evidenced by IL-1β, enhanced host protective functions.
Keyphrases
- candida albicans
- immune response
- endothelial cells
- biofilm formation
- pseudomonas aeruginosa
- staphylococcus aureus
- climate change
- induced pluripotent stem cells
- social support
- cancer therapy
- dendritic cells
- toll like receptor
- emergency department
- escherichia coli
- cystic fibrosis
- adverse drug
- drug delivery
- inflammatory response