Is headache a risk factor for dementia? A systematic review and meta-analysis.
Aurora CermelliFausto RovetaLia GiorgisSilvia BoschiAlberto GrassiniFabio FerrandesChiara LombardoAndrea MarcinnòElisa RubinoInnocenzo RaineroPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2023)
Our study supports the presence of a link between primary headaches and dementia. However, in the subgroup analysis, only patients with migraine showed a moderate increase risk for all-cause dementia and for Alzheimer's disease. Additional rigorous studies are needed to elucidate the possible role of primary headaches on the risk of developing cognitive impairment and dementia.