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Is headache a risk factor for dementia? A systematic review and meta-analysis.

Aurora CermelliFausto RovetaLia GiorgisSilvia BoschiAlberto GrassiniFabio FerrandesChiara LombardoAndrea MarcinnòElisa RubinoInnocenzo Rainero
Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2023)
Our study supports the presence of a link between primary headaches and dementia. However, in the subgroup analysis, only patients with migraine showed a moderate increase risk for all-cause dementia and for Alzheimer's disease. Additional rigorous studies are needed to elucidate the possible role of primary headaches on the risk of developing cognitive impairment and dementia.
Keyphrases
  • cognitive impairment
  • mild cognitive impairment
  • cognitive decline
  • randomized controlled trial
  • high intensity
  • phase iii
  • data analysis