Novel Mouse Model of Myocardial Infarction, Plaque Rupture, and Stroke Shows Improved Survival With Myeloperoxidase Inhibition.
Sohel ShamsuzzamanRebecca A DeatonAnita SalamonHeather DoviakVlad SerbuleaVictoria M MilosekMegan A EvansSantosh KarnewarSubhi SaibabaGabriel F AlencarLaura S ShankmanKenneth WalshStefan BekiranovOlivier KocherMonty KriegerBengt KullMarie PerssonErik MichaëlssonNils BergenhemSepideh Heydarkhan-HagvallGary K OwensPublished in: Circulation (2024)
mice more closely replicate late-stage clinical events of advanced human atherosclerotic disease than previous models and can be used to identify and test potential new therapeutic agents to prevent major adverse cardiac events.
Keyphrases
- mouse model
- left ventricular
- endothelial cells
- atrial fibrillation
- heart failure
- induced pluripotent stem cells
- coronary artery disease
- high fat diet induced
- pluripotent stem cells
- type diabetes
- emergency department
- adipose tissue
- free survival
- brain injury
- insulin resistance
- climate change
- risk assessment
- metabolic syndrome
- subarachnoid hemorrhage