Therapeutic Effect of Prolyl Endopeptidase Inhibitor in High-fat Diet-induced Metabolic Dysfunction-associated Fatty Liver Disease.

Jian-Bin ZhangMeng-Ting LiShuang-Zhe LinYu-Qing ChengJian-Gao Fan Yuan-Wen Chen

Published in: Journal of clinical and translational hepatology (2023)

These findings suggest that increased PREP activity/expression during MAFLD development might be a key factor in the transition from simple steatosis to steatohepatitis, and KYP-2047 might possess therapeutic potential for MAFLD treatment.

Keyphrases

high fat diet induced
insulin resistance
poor prognosis
high fat diet
oxidative stress
metabolic syndrome
skeletal muscle
liver fibrosis
replacement therapy
smoking cessation