Effect of sigma E on carbapenem resistance in OXA-48-producing Klebsiella pneumoniae.

Martina CremannsFelix LangeSören G GatermannNiels Pfennigwerth

Published in: The Journal of antimicrobial chemotherapy (2022)

Enhanced synthesis of σE leads to increased resistance to cephalosporins and carbapenems in clinical K. pneumoniae isolates. This effect could be based upon remodelling of expression patterns of outer membrane proteins. The up-regulated σE stress response also leads to a significant reduction in growth rates.

Keyphrases

klebsiella pneumoniae
multidrug resistant
escherichia coli
poor prognosis
acinetobacter baumannii
transcription factor
drug resistant
gram negative
binding protein
cystic fibrosis
pseudomonas aeruginosa