Homeostatic Regulation of Interneuron Apoptosis During Cortical Development.
Myrto DenaxaGuilherme NevesJuan BurroneVassilis PachnisPublished in: Journal of experimental neuroscience (2018)
The mammalian cortex consists of two main neuronal types: the principal excitatory pyramidal neurons (PNs) and the inhibitory interneurons (INs). The interplay between these two neuronal populations - which drive excitation and inhibition (E/I balance), respectively - is crucial for controlling the overall activity in the brain. A number of neurological and psychiatric disorders have been associated with changes in E/I balance. It is not surprising, therefore, that neural networks employ several different mechanisms to maintain their firing rates at a stable level, collectively referred as homeostatic forms of plasticity. Here, we share our views on how the size of IN populations may provide an early homeostatic checkpoint for controlling brain activity. In a recent paper published in Cell Reports, we demonstrate that the extent of IN apoptosis during a critical early postnatal period is plastic, cell type specific, and can be reduced in a cell-autonomous manner by acute increases in neuronal activity. We propose that a critical interplay between the physiological state of the network and its cellular units fine-tunes the size of IN populations with the aim of stabilizing network activity.
Keyphrases
- cerebral ischemia
- neural network
- oxidative stress
- single cell
- endoplasmic reticulum stress
- cell death
- cell therapy
- dna damage
- cell cycle arrest
- preterm infants
- spinal cord
- liver failure
- systematic review
- emergency department
- air pollution
- genetic diversity
- mesenchymal stem cells
- white matter
- randomized controlled trial
- brain injury
- bone marrow
- intensive care unit
- spinal cord injury
- hepatitis b virus
- signaling pathway
- adverse drug
- mechanical ventilation