Inflammation during early post-acute COVID-19 is associated with reduced exercise capacity and Long COVID symptoms after 1 year.
Matthew S DurstenfeldMichael J PelusoPunita KavetiChristopher HillDanny LiErica SanderShreya SwaminathanVictor M ArechigaKaiwen SunYifei MaVictor ZepedaScott LuSarah A GoldbergRebecca HohAhmed ChennaBrandon C YeeJohn W WinslowChristos J PetroupoulosSithu WinJ Daniel KellyDavid V GliddenTimothy J HenrichJeffrey N MartinYoo Jin LeeMandar A ArasCarlin S LongDonald J GrandisSteven G DeeksPriscilla Y HsuePublished in: medRxiv : the preprint server for health sciences (2022)
Cardiopulmonary testing to identify etiologies of persistent symptoms in post-acute sequalae of COVID-19 or "Long COVID" should be performed in a manner that allows for assessment of heart rate response to exercise.Therapeutic trials of anti-inflammatory and exercise strategies in PASC are urgently needed and should include assessment of symptoms and objective testing with cardiopulmonary exercise testing.
Keyphrases
- coronavirus disease
- sars cov
- heart rate
- high intensity
- physical activity
- liver failure
- resistance training
- heart rate variability
- blood pressure
- anti inflammatory
- respiratory syndrome coronavirus
- sleep quality
- drug induced
- intensive care unit
- depressive symptoms
- hepatitis b virus
- extracorporeal membrane oxygenation