ChREBP-driven DNL and PNPLA3 Expression Induced by Liquid Fructose are Essential in the Production of Fatty Liver and Hypertriglyceridemia in a High-Fat Diet-Fed Rat Model.

Ana Magdalena VelázquezRoger BentanachsAleix Sala-VilaIolanda LázaroJose Rodríguez-MoratóRosa M SánchezMarta AlegretNúria RoglansJuan Carlos Laguna

Published in: Molecular nutrition & food research (2022)

The addition of liquid-fructose to dietary FA is determinant in liver steatosis and hypertriglyceridemia production, through increased DNL and PNPLA3 expression, and reduced FA catabolism.

Keyphrases

high fat diet
insulin resistance
poor prognosis
adipose tissue
ionic liquid
binding protein
metabolic syndrome
high fat diet induced