Tumor microenvironment-mediated immune profiles and efficacy of anti-PD-L1 antibody plus chemotherapy stratified by DLL3 expression in small-cell lung cancer.
Masayuki ShirasawaTatsuya YoshidaKouya ShiraishiNaoko GotoShigehiro YagishitaTatsuya ImabayashiYuji MatsumotoKen MasudaYuki ShinnoYusuke OkumaYasushi GotoHidehito HorinouchiMasaya YotsukuraYukihiro YoshidaKazuo NakagawaKatsuhiko NaokiTakaaki TsuchidaRyuji HamamotoNoboru YamamotoNoriko MotoiTakashi KohnoShun-Ichi WatanabeYuichiro OhePublished in: British journal of cancer (2023)
had a higher neoantigen load, these tumors were resistant to immunochemotherapy due to suppressed tumor immunity by inhibiting antigen-presenting functions.