M. tuberculosis antigen-responsive IL17 + CD4 T cells are disproportionately spared in ART-suppressed HIV.
Paul OgongoAnthony TranFlorence MarzanDavid GingrichMelissa KroneFrancesca AweekaCecilia S Lindestam ArlehamnJeffrey N MartinSteven G DeeksPeter W HuntJoel D ErnstPublished in: bioRxiv : the preprint server for biology (2023)
We found differential effects of ART-suppressed HIV on distinct categories of Th17 cells, that IL17-producing CD4 T cells dominate responses to Mtb but not CMV antigen or SEB, and that kynurenine pathway activity is associated with selective decreases of circulating Th17 cells that may contribute to tuberculosis immunity.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv aids
- induced apoptosis
- mycobacterium tuberculosis
- hiv positive
- human immunodeficiency virus
- cell cycle arrest
- pulmonary tuberculosis
- hiv testing
- hepatitis c virus
- men who have sex with men
- endoplasmic reticulum stress
- cell death
- oxidative stress
- cancer therapy
- pi k akt
- drug induced