Revising the Role of Integrin Subunit β4 Expression in Colon Cancer Progression and Survival.
Eva RademakerEsther BastiaannetJan OostingNeeltje G Dekker-EnsinkPeter J K KuppenNoel F C C de MirandaGerrit Jan LiefersPublished in: Journal of gastrointestinal cancer (2022)
Contradictory reports have suggested opposite roles for β4 expression in (colon) cancer progression. In the present large cohort of colon cancer patients, we found that β4 expression was not associated with worse clinical prognosis, but decreased with advanced pathological tumor stage. Future studies should establish whether loss of β4 expression promotes invasive characteristics of colon cancer cells.