A subset of conserved mammalian long non-coding RNAs are fossils of ancestral protein-coding genes.

Hadas HezroniRotem Ben-Tov PerryZohar MeirGali HousmanYoav LubelskyIgor Ulitsky

Published in: Genome biology (2017)

We estimate that ~ 55 annotated conserved human lncRNAs are derived from parts of ancestral protein-coding genes, and loss of coding potential is thus a non-negligible source of new lncRNAs. Some lncRNAs inherited regulatory elements influencing transcription and translation from their protein-coding ancestors and those elements can influence the expression breadth and functionality of these lncRNAs.

Keyphrases

genome wide identification
transcription factor
long non coding rna
genome wide analysis
poor prognosis
binding protein
network analysis
amino acid
gene expression
dna methylation
climate change
induced pluripotent stem cells