Epigenetic conditioning induces intergenerational resilience to dementia in a mouse model of vascular cognitive impairment.
Krystal Courtney D BelmonteEleanor B HolmgrenTiffany A WillsJeffrey M GiddayPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)
Our results in experimental VCID underscore the efficacy of epigenetics-based treatments to prevent memory loss, and demonstrate for the first time the heritability of an induced resilience to dementia.