Epigenetic conditioning induces intergenerational resilience to dementia in a mouse model of vascular cognitive impairment.

Krystal Courtney D BelmonteEleanor B HolmgrenTiffany A WillsJeffrey M Gidday

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)

Our results in experimental VCID underscore the efficacy of epigenetics-based treatments to prevent memory loss, and demonstrate for the first time the heritability of an induced resilience to dementia.

Keyphrases

cognitive impairment
mouse model
mild cognitive impairment
climate change
social support
high glucose
dna methylation
diabetic rats
gene expression
working memory
drug induced
oxidative stress
depressive symptoms
endothelial cells