Prognostic significance of BAP1 expression in high-grade upper tract urothelial carcinoma: a multi-institutional study.

Ahmet M AydinNirmish SinglaVandana PanwarSolomon L WolduYuval FreifeldChristopher G WoodJose A KaramAlon Z WeizerJay D RamanMesut RemziNathalie Rioux-LeclercqAndrea HaitelMarco RoscignoChristian BolenzKarim BensalahMary E WestermanArthur I SagalowskyShahrokh F ShariatYair LotanAditya BagrodiaPayal KapurVitaly MargulisLaura-Maria Krabbe

Published in: World journal of urology (2019)

BAP1 loss was associated with favorable pathologic features and better oncologic outcomes in univariate but not multivariate analysis in patients with high-grade UTUC. In contrast to renal cell carcinoma, loss of BAP1 expression appears to confer a better prognosis in high-grade UTUC. The role of the BAP1 pathway in UTUC pathogenesis remains to be further elucidated.

Keyphrases

high grade
low grade
poor prognosis
renal cell carcinoma
magnetic resonance
binding protein
neoadjuvant chemotherapy
long non coding rna
magnetic resonance imaging
rectal cancer
prostate cancer
computed tomography
metabolic syndrome
locally advanced
type diabetes
lymph node
skeletal muscle