Application of population physiologically based pharmacokinetic modelling to optimize target expression and clearance mechanisms of therapeutic monoclonal antibodies.

Javier Reig-LopezWeifeng TangCarlos Fernandez-TeruelMatilde Merino-SanjuanVictor Mangas SanjuanDavid W BoultonPradeep Sharma

Published in: British journal of clinical pharmacology (2023)

Optimisation of both system and drug related parameters were performed through PBPK modelling to improve model performance of therapeutic mAbs (PTZ, TTZ and CTX). General workflow was proposed to develop and apply PopPBPK to support clinical development of mAbs targeting same receptor.

Keyphrases

poor prognosis
binding protein
klebsiella pneumoniae
escherichia coli
electronic health record
drug delivery
multidrug resistant