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How modelling can help steer the course set by the World Health Organization 2021-2030 roadmap on neglected tropical diseases.

Jessica ClarkWilma A StolkMaría-Gloria BasáñezLuc E CoffengZulma M CucunubáMatthew A DixonLouise DysonKatie HampsonMichael MarksGraham F MedleyTimothy M PollingtonJoaquín M PradaKat S RockHenrik SaljeJaspreet ToorT Deirdre Hollingsworth
Published in: Gates open research (2022)
The World Health Organization recently launched its 2021-2030 roadmap, Ending the Neglect to Attain the Sustainable Development Goals , an updated call to arms to end the suffering caused by neglected tropical diseases. Modelling and quantitative analyses played a significant role in forming these latest goals. In this collection, we discuss the insights, the resulting recommendations and identified challenges of public health modelling for 13 of the target diseases: Chagas disease, dengue, gambiense human African trypanosomiasis (gHAT), lymphatic filariasis (LF), onchocerciasis, rabies, scabies, schistosomiasis, soil-transmitted helminthiases (STH), Taenia solium taeniasis/ cysticercosis, trachoma, visceral leishmaniasis (VL) and yaws. This piece reflects the three cross-cutting themes identified across the collection, regarding the contribution that modelling can make to timelines, programme design, drug development and clinical trials.
Keyphrases
  • public health
  • clinical trial
  • climate change
  • endothelial cells
  • zika virus
  • lymph node
  • randomized controlled trial
  • high resolution
  • dengue virus
  • clinical practice
  • induced pluripotent stem cells