Beneficial effects of hepatic cyclooxygenase-2 expression against cholestatic injury after common bile duct ligation in mice.

Rocío Brea Natalia Casanova Carlota Alvarez-Lucena Marina Fuertes-Agudo María Luque-Tévar Carme Cucarella María C Capitani María V Marinochi Matías E Fusini Agustin Lahoz Marina López Nogueroles Juan Fraile María T Ronco Lisardo Boscá Águeda González-Rodríguez Carmelo García-Monzón Paloma Martín-Sanz Marta Casado Daniel E Francés

Published in: Liver international : official journal of the International Association for the Study of the Liver (2024)

Taken together, our data indicate that constitutive expression of COX-2 in hepatocytes ameliorates cholestatic liver injury in mice by reducing inflammation and cell damage and by modulating BA metabolism, pointing to a role for COX-2 as a defensive response against cholestasis-derived BA accumulation and injury.

Keyphrases

liver injury
drug induced
poor prognosis
oxidative stress
high fat diet induced
single cell
binding protein
signaling pathway
cell therapy
mouse model
long non coding rna
big data
insulin resistance
skeletal muscle
wild type
adipose tissue
mesenchymal stem cells
metabolic syndrome