4-phenylbutyric acid promotes hepatocellular carcinoma via initiating cancer stem cells through activation of PPAR-α.
Shu-Zhen ChenYan LingLe-Xing YuYu-Ting SongXiao-Fei ChenQi-Qi CaoHan YuCan ChenJiao-Jiao TangZhe-Cai FanYu-Shan MiaoYa-Ping DongJun-Yan TaoSatdarshan P S MongaWen WenHong-Yang WangPublished in: Clinical and translational medicine (2022)
4-PBA could upregulate PPAR-α to initiate LCSCs by activating β-catenin signaling pathway, promoting HCC at early stage. Therefore, more discretion should be taken to monitor the potential tumor-promoting effect of 4-PBA under HCC-inducing environment.