[Influence of siRNA complexes on the reproduction of influenza A virus (Orthomyxoviridae: Alphainfluenzavirus ) in vivo ].

E A Pashkov V Y Momot A V Pak R V Samoilikov G A Pashkov G N Usatova E O Kravtsova Alexander V Poddubikov F G Nagieva A V Sidorov E P Pashkov Oksana Svitich V V Zverev

Published in: Voprosy virusologii (2023)

The use of siRNAs in vivo can lead to an antiviral effect when the activity of single or several cellular genes is suppressed. The results indicate that the use of siRNAs targeting the cellular genes whose expression products are involved in viral reproduction is one of the promising methods for the prevention and treatment of not only influenza, but also other respiratory infections.

Keyphrases

genome wide
cancer therapy
poor prognosis
bioinformatics analysis
sars cov
genome wide identification
transcription factor
combination therapy
long non coding rna
gene expression
dna methylation