Neonatal kaempferol exposure attenuates impact of cerebral palsy model on neuromotor development, cell proliferation, microglia activation, and antioxidant enzyme expression in the hippocampus of rats.
Diego Bulcão ViscoRaul Manhães-de-CastroMárcia Maria da SilvaBárbara J R Costa-de-SantanaJoaci Pereira Dos Santos JuniorLuís Miguel SaavedraMaria Daniele Teixeira Beltrão de LemosJuan José Valdéz-AlarcónClaudia Jacques LagranhaOmar Guzman-QuevedoLuz TornerAna Elisa ToscanoPublished in: Nutritional neuroscience (2022)
Kaempferol attenuates the impact of cerebral palsy on neuromotor behavior development, preventing altered hippocampal microglia activation and mitigating impaired cell proliferation in a neurogenic niche in these rats. Neonatal treatment with kaempferol also increases antioxidant defense gene expression in the hippocampus of rats submitted to the cerebral palsy model.
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