Lipid raft-disrupting miltefosine preferentially induces the death of colorectal cancer stem-like cells.
So-Yeon ParkJee-Heun KimJang-Hyun ChoiChoong-Jae LeeWon-Jae LeeSehoon ParkZee-Yong ParkJeong-Heum BaekJeong-Seok NamPublished in: Clinical and translational medicine (2022)
Our findings underscore the therapeutic potential of LR-targeting APLs for CRC treatment that overcomes the therapy-resistant phenotype of CSCs, highlighting the importance of the LR/CHEK1 axis as a novel mechanism of APLs.