The host defense peptide LL-37 is internalized by human periodontal ligament cells and prevents LPS-induced MCP-1 production.

Alexandra AidoukovitchEmma AndersSara DahlDaniel NebelDaniel SvenssonBengt-Olof Nilsson

Published in: Journal of periodontal research (2019)

LL-37 abolishes LPS-induced MCP-1 production in human PDL cells through an intracellular, NF-κB-independent mechanism which probably involves direct interaction between LL-37 and DNA.

Keyphrases

lps induced
inflammatory response
induced apoptosis
endothelial cells
cell cycle arrest
oxidative stress
signaling pathway
endoplasmic reticulum stress
pluripotent stem cells
cell death
toll like receptor
pi k akt
cell free
nuclear factor