Short-course amphotericin B in addition to sertraline and fluconazole for treatment of HIV-associated cryptococcal meningitis in rural Tanzania.
Andrew KatendeGladys MbwanjiDiana FainiAmina NyuriAneth Vedastus KalinjumaDorcas MnzavaKatherine H HullsiekJoshua RheinMaja WeisserDavid B MeyaDavid R BoulwareEmilio Letangnull nullPublished in: Mycoses (2019)
Short-course amphotericin substantially increased CSF clearance and 10-week survival. Adjunctive sertraline improved 2-week CSF fungal clearance but did not improve 10-week mortality compared with published data using fluconazole 1200 mg/day monotherapy (early fungicidal activity 0.15 log10 CFU/mL/day).
Keyphrases
- candida albicans
- cerebrospinal fluid
- antiretroviral therapy
- combination therapy
- hiv positive
- hiv infected
- placebo controlled
- human immunodeficiency virus
- south africa
- hepatitis c virus
- cardiovascular events
- electronic health record
- hiv testing
- hiv aids
- risk factors
- systematic review
- clinical trial
- coronary artery disease
- randomized controlled trial
- cardiovascular disease
- data analysis
- deep learning
- free survival
- artificial intelligence
- double blind