Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.
Derek KlarinQiuyu Martin ZhuConnor A EmdinMark ChaffinSteven HornerBrian J McMillanAlison LeedMichael E WealeChris C A SpencerFrançois AguetAyellet V SegrèKristin G ArdlieAmit V KheraVirendar K KaushikPradeep Natarajannull nullSekar KathiresanPublished in: Nature genetics (2017)
UK Biobank is among the world's largest repositories for phenotypic and genotypic information in individuals of European ancestry. We performed a genome-wide association study in UK Biobank testing ∼9 million DNA sequence variants for association with coronary artery disease (4,831 cases and 115,455 controls) and carried out meta-analysis with previously published results. We identified 15 new loci, bringing the total number of loci associated with coronary artery disease to 95 at the time of analysis. Phenome-wide association scanning showed that CCDC92 likely affects coronary artery disease through insulin resistance pathways, whereas experimental analysis suggests that ARHGEF26 influences the transendothelial migration of leukocytes.
Keyphrases
- coronary artery disease
- genome wide association study
- insulin resistance
- percutaneous coronary intervention
- cardiovascular events
- coronary artery bypass grafting
- systematic review
- adipose tissue
- type diabetes
- metabolic syndrome
- high fat diet
- cardiovascular disease
- genome wide
- healthcare
- meta analyses
- peripheral blood
- copy number
- single molecule
- social media
- circulating tumor
- glycemic control
- amino acid
- acute coronary syndrome
- transcatheter aortic valve replacement
- ejection fraction