Meta-transcriptomics reveals a diverse antibiotic resistance gene pool in avian microbiomes.
Vanessa Rossetto MarcelinoMichelle WilleAeron C HurtDaniel González-AcuñaMarcel KlaassenTimothy E SchlubJohn-Sebastian EdenMang ShiJonathan R IredellTania C SorrellEdward C HolmesPublished in: BMC biology (2019)
These transcriptome data suggest that human waste, even if it undergoes treatment, might contribute to the spread of antibiotic resistance genes to the wild. Differences in microbiome functioning across different bird lineages may also play a role in the antibiotic resistance burden carried by wild birds. In summary, we reveal the complex factors explaining the distribution of resistance genes and their exchange routes between humans and wildlife, and show that meta-transcriptomics is a valuable tool to access functional resistance genes in whole microbial communities.
Keyphrases
- genome wide
- single cell
- antibiotic resistance genes
- genome wide identification
- dna methylation
- rna seq
- wastewater treatment
- copy number
- microbial community
- endothelial cells
- genome wide analysis
- gene expression
- bioinformatics analysis
- heavy metals
- anaerobic digestion
- transcription factor
- electronic health record
- genetic diversity
- induced pluripotent stem cells
- pluripotent stem cells
- big data
- combination therapy