Prognostic and therapeutic implications of NHERF1 expression and regulation in colorectal cancer.

Premila Devi LeiphrakpamAudrey J LazenbySanjib ChowdhuryLynette M SmithMichelle MathiesenMichael G BrattainJing WangJennifer D BlackChandrakanth Are

Published in: Journal of surgical oncology (2019)

NHERF1 expression levels correlated with worse prognosis in patients with CRC and plays a critical role in CRC cell survival. Together, our findings establish NHERF1 as a novel potential marker for increased risk of CRC-specific mortality and identify NHERF1 as an attractive therapeutic target for mCRC treatment.

Keyphrases

poor prognosis
binding protein
cardiovascular events
cardiovascular disease
risk assessment
climate change
combination therapy