MicroRNA-155 acts as a potential prognostic and diagnostic factor in patients with ankylosing spondylitis by modulating SOCS3.

Mohammadsaleh JahangirMohammad Saeed KahriziMohammad NatamiRaziyeh Moaref PourShadi GhoreishizadehMaryam HemmatzadehHamed MohammadiNavid ShomaliSiamak Sandoghchian Shotorbani

Published in: Molecular biology reports (2022)

miR-155 acts as a potential prognostic and diagnostic biomarker. Its up-regulation leads to the down-regulation of SOCS3 and increased expression of IL-21 and STAT3 as characteristic of TH-17 lymphocytes, leading to worsening inflammatory conditions in patients with AS.

Keyphrases

ankylosing spondylitis
cell proliferation
poor prognosis
long non coding rna
rheumatoid arthritis
disease activity
oxidative stress
human health
signaling pathway
peripheral blood
long noncoding rna
systemic lupus erythematosus
binding protein
climate change