Omentin1 ameliorates myocardial ischemia-induced heart failure via SIRT3/FOXO3a-dependent mitochondrial dynamical homeostasis and mitophagy.
Jingui HuTao LiuFei FuZekun CuiQiong LaiYuanyuan ZhangBoyang YuFuming LiuJunping KouFang LiPublished in: Journal of translational medicine (2022)
Omentin1 improves MI-induced HF and myocardial injury by maintaining mitochondrial dynamical homeostasis and activating mitophagy via upregulation of SIRT3/FOXO3a signaling. This study provides evidence for further application of omentin1 in cardiovascular diseases from the perspective of crosstalk between heart and adipose tissue.
Keyphrases
- oxidative stress
- heart failure
- diabetic rats
- signaling pathway
- adipose tissue
- left ventricular
- high glucose
- cardiovascular disease
- transcription factor
- pi k akt
- density functional theory
- ischemia reperfusion injury
- drug induced
- insulin resistance
- nlrp inflammasome
- poor prognosis
- cell proliferation
- acute heart failure
- metabolic syndrome
- long non coding rna
- cardiovascular events