Hypomethylation-activated cancer-testis gene SPANXC promotes cell metastasis in lung adenocarcinoma.
Xuewei WangSihan JuYao ChenQufei QianCaiwang YanShuaizhou ChenYuting ChangYide XuZijian MaChang ZhangNa QinYayun GuCheng WangErbao ZhangZhi-Bin HuPublished in: Journal of cellular and molecular medicine (2019)
Many studies have shown that there were similarity between tumorigenesis and gametogenesis. Our previous work found that cancer-testis (CT) genes could serve as a novel source of candidate of cancer. Here, by analysing The Cancer Genome Atlas (TCGA) database, we characterized a CT gene, SPANXC, which is expressed only in testis. The SPANXC was reactivated in lung adenocarcinoma (LUAD) tissues. And the expression of SPANXC was associated with prognosis of LUAD. We also found that the activation of SPANXC was due to the promoter hypomethylation of SPANXC. Moreover, SPANXC could modulate cell metastasis both in vitro and in vivo. Mechanistically, we found that SPANXC could bind to ROCK1, a metastasis-related gene, and thus SPANXC may regulate cell metastasis partly through interaction with ROCK1 in LUAD. Together, our results demonstrated that the CT expression pattern of SPANXC served as a crucial role in metastasis of LUAD. And these data further corroborated the resemblance between processes of germ cell development and tumorigenesis, including migration and invasion.
Keyphrases
- papillary thyroid
- single cell
- genome wide
- squamous cell
- germ cell
- computed tomography
- poor prognosis
- cell therapy
- image quality
- gene expression
- dual energy
- magnetic resonance imaging
- stem cells
- genome wide identification
- squamous cell carcinoma
- childhood cancer
- long non coding rna
- young adults
- bone marrow
- case control