Degree of Fibrosis in Human Atrial Tissue Is Not the Hallmark Driving AF.
Kennedy S RamosLisa PoolMathijs S van SchieLeonoor F J M WijdeveldWillemijn F B van der DoesLuciënne BaksH M Danish SultanStan W van WijkAd J J C BogersSander VerheuleNatasja M S De GrootBianca J J M BrundelPublished in: Cells (2022)
No differences in the degree of fibrosis were observed in patients from various stages of AF compared to the controls. Moreover, electrophysiological abnormalities did not correlate with any of the fibrosis markers. The findings indicate that fibrosis is not the hallmark of structural remodeling in AF.