Functionalization of Tetrazoles Bearing the Electrochemically Cleavable 1 N -(6-Methylpyridyl-2-methyl) Protecting Group.
Konstantinos GrammatoglouMadara Da RziņaAigars JirgensonsPublished in: ACS omega (2022)
6-Methylpyridyl-2-methyl protected tetrazoles can be C-H deprotonated using the turbo-Grignard reagent and involved in the reactions with aldehydes and ketones. The protecting group can be cleaved under reductive electrochemical conditions using Pb bronze as a cathode and Zn as a sacrificial anode.