Aigars Jirgensons

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 36

Top Topics

Plasmodium Falciparum

Structure Activity Relationship

Top Venues

Journal of medicinal chemistry

Organic letters

ACS infectious diseases

Chemistry (Weinheim an der Bergstrasse, Germany)

This page only lists publications with an associated author ORCID identifier.

Publications

Raitis Bobrovs, Svetlana Terentjeva, Ninni Elise Olafsen, Zilvinas Dambrauskas, Antanas Gulbinas, Toivo Maimets, Indrek Teino, Aigars Jirgensons, Jason Matthews, Kristaps Jaudzems
Discovery and optimisation of pyrazolo[1,5- a ]pyrimidines as aryl hydrocarbon receptor antagonists. RSC medicinal chemistry (2024)
Albertina Scattolini, Konstantinos Grammatoglou, Anna Nikitjuka, Aigars Jirgensons, María Cecilia Mansilla, Björn Windshügel
Substrate Analogues Entering the Lipoic Acid Salvage Pathway via Lipoate-Protein Ligase 2 Interfere with Staphylococcus aureus Virulence. ACS infectious diseases 10 (6) (2024)
Xavier Jalencas, Hannes Berg, Ludvik Olai Espeland, Sridhar Sreeramulu, Franziska Kinnen, Christian Richter, Charis Georgiou, Vladyslav Yadrykhins'ky, Edgar Specker, Kristaps Jaudzems, Tanja Miletić, Robert K Harmel, Philip Gribbon, Harald Schwalbe, Ruth Brenk, Aigars Jirgensons, Andrea Zaliani, Jordi Mestres
Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection. RSC medicinal chemistry 15 (4) (2024)
Xavier Jalencas, Hannes Berg, Ludvik Olai Espeland, Sridhar Sreeramulu, Franziska Kinnen, Christian Richter, Charis Georgiou, Vladyslav Yadrykhins'ky, Edgar Specker, Kristaps Jaudzems, Tanja Miletić, Robert K Harmel, Philip Gribbon, Harald Schwalbe, Ruth Brenk, Aigars Jirgensons, Andrea Zaliani, Jordi Mestres
Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection. RSC medicinal chemistry 15 (4) (2024)
Madara Darzina, Aigars Jirgensons
Electrochemical Formation of Oxazolines by 1,3-Oxyfluorination of Non-activated Cyclopropanes. Organic letters (2024)
Andrii Hrebonkin, Sergii Afonin, Anna Nikitjuka, Oleksandr V Borysov, Gundars Leitis, Oleg Babii, Serhii Koniev, Theo Lorig, Stephan L Grage, Peter Nick, Anne S Ulrich, Aigars Jirgensons, Igor V Komarov
Spiropyran-Based Photoisomerizable α-Amino Acid for Membrane-Active Peptide Modification. Chemistry (Weinheim an der Bergstrasse, Germany) 30 (22) (2024)
Andrii Hrebonkin, Sergii Afonin, Anna Nikitjuka, Oleksandr V Borysov, Gundars Leitis, Oleg Babii, Serhii Koniev, Theo Lorig, Stephan L Grage, Peter Nick, Anne S Ulrich, Aigars Jirgensons, Igor V Komarov
Spiropyran-Based Photoisomerizable α-Amino Acid for Membrane-Active Peptide Modification. Chemistry (Weinheim an der Bergstrasse, Germany) (2024)
Chrislaine Withers-Martinez, Elina Lidumniece, Fiona Hackett, Christine R Collins, Zahie Taha, Michael J Blackman, Aigars Jirgensons
Peptidic Boronic Acid Plasmodium falciparum SUB1 Inhibitors with Improved Selectivity over Human Proteasome. Journal of medicinal chemistry (2024)
Chrislaine Withers-Martinez, Elina Lidumniece, Fiona Hackett, Christine R Collins, Zahie Taha, Michael J Blackman, Aigars Jirgensons
Peptidic Boronic Acid Plasmodium falciparum SUB1 Inhibitors with Improved Selectivity over Human Proteasome. Journal of medicinal chemistry 67 (15) (2024)
Andrii Hrebonkin, Sergii Afonin, Anna Nikitjuka, Oleksandr V Borysov, Gundars Leitis, Oleg Babii, Serhii Koniev, Theo Lorig, Stephan L Grage, Peter Nick, Anne S Ulrich, Aigars Jirgensons, Igor V Komarov
Spiropyran-Based Photoisomerizable α-Amino Acid for Membrane-Active Peptide Modification. Chemistry (Weinheim an der Bergstrasse, Germany) 30 (22) (2024)
Albertina Scattolini, Konstantinos Grammatoglou, Anna Nikitjuka, Aigars Jirgensons, María Cecilia Mansilla, Björn Windshügel
Substrate Analogues Entering the Lipoic Acid Salvage Pathway via Lipoate-Protein Ligase 2 Interfere with Staphylococcus aureus Virulence. ACS infectious diseases 10 (6) (2024)
Albertina Scattolini, Konstantinos Grammatoglou, Anna Nikitjuka, Aigars Jirgensons, María Cecilia Mansilla, Björn Windshügel
Substrate Analogues Entering the Lipoic Acid Salvage Pathway via Lipoate-Protein Ligase 2 Interfere with Staphylococcus aureus Virulence. ACS infectious diseases (2024)
Georgijs Stakanovs, Anastasija Blazevica, Dace Rasina, Sergey Belyakov, Aigars Jirgensons
Bioinspired Semisynthesis and Structure Revisions of Chlorinated Norsesquiterpenoids Rumphellatins A-C. Organic letters (2024)
Albertina Scattolini, Konstantinos Grammatoglou, Anna Nikitjuka, Aigars Jirgensons, María Cecilia Mansilla, Björn Windshügel
Substrate Analogues Entering the Lipoic Acid Salvage Pathway via Lipoate-Protein Ligase 2 Interfere with Staphylococcus aureus Virulence. ACS infectious diseases 10 (6) (2024)
Madara Darzina, Aigars Jirgensons
Electrochemical Formation of Oxazolines by 1,3-Oxyfluorination of Non-activated Cyclopropanes. Organic letters 26 (11) (2024)
Chrislaine Withers-Martinez, Elina Lidumniece, Fiona Hackett, Christine R Collins, Zahie Taha, Michael J Blackman, Aigars Jirgensons
Peptidic Boronic Acid Plasmodium falciparum SUB1 Inhibitors with Improved Selectivity over Human Proteasome. Journal of medicinal chemistry 67 (15) (2024)
Vadims Kovada, Chrislaine Withers-Martinez, Raitis Bobrovs, Hele Na Ce Rule, Edgars Liepins, Solveiga Grinberga, Fiona Hackett, Christine R Collins, Agrita Kreicberga, María Belén Jiménez-Díaz, Iñigo Angulo-Barturen, Dace Rasina, Edgars Suna, Kristaps Jaudzems, Michael J Blackman, Aigars Jirgensons
Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity. Journal of medicinal chemistry (2023)
Joseph Becica, Olavs Ra Ciņš, Marija Ivanova, Aigars Jirgensons
Assembling the Methanoindene Cage of Phragmalin-Type Natural Products. The Journal of organic chemistry (2023)
Jekaterina Bolsakova, Raitis Bobrovs, Larisa Varacheva, Anastasija Rudnickiha, Iveta Kanepe, Emilio Parisini, Aigars Jirgensons
Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library. ACS medicinal chemistry letters 15 (1) (2023)
Georgijs Stakanovs, Anastasija Blazevica, Sergey Belyakov, Dace Rasina, Aigars Jirgensons
Semisynthesis of Linariophyllenes A-C and Rumphellolide H, Structure Revisions and Proposed Biosynthesis Pathways. Journal of natural products (2023)
Jekaterina Bolsakova, Raitis Bobrovs, Larisa Varacheva, Anastasija Rudnickiha, Iveta Kanepe, Emilio Parisini, Aigars Jirgensons
Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library. ACS medicinal chemistry letters 15 (1) (2023)
Jhon Alexander Rodriguez Buitrago, Gundars Leitis, Iveta Kaņepe-Lapsa, Anastasija Rudnickiha, Emilio Parisini, Aigars Jirgensons
Synthesis and evaluation of an agrocin 84 toxic moiety (TM84) analogue as a malarial threonyl tRNA synthetase inhibitor. Organic & biomolecular chemistry (2023)
Raitis Bobrovs, Laura Drunka, Iveta Kanepe, Aigars Jirgensons, Amedeo Caflisch, Matteo Salvalaglio, Kristaps Jaudzems
Exploring the Binding Pathway of Novel Nonpeptidomimetic Plasmepsin V Inhibitors. Journal of chemical information and modeling (2023)
Konstantinos Grammatoglou, Aigars Jirgensons
Functionalization of 1 N -Protected Tetrazoles by Deprotonation with the Turbo Grignard Reagent. The Journal of organic chemistry 87 (5) (2022)
Konstantinos Grammatoglou, Madara Da Rziņa, Aigars Jirgensons
Functionalization of Tetrazoles Bearing the Electrochemically Cleavable 1 N -(6-Methylpyridyl-2-methyl) Protecting Group. ACS omega 7 (21) (2022)
Elina Lidumniece, Chrislaine Withers-Martinez, Fiona Hackett, Michael J Blackman, Aigars Jirgensons
Subtilisin-like Serine Protease 1 (SUB1) as an Emerging Antimalarial Drug Target: Current Achievements in Inhibitor Discovery. Journal of medicinal chemistry 65 (19) (2022)
Georgijs Stakanovs, Sergey Belyakov, Aigars Jirgensons, Dace Rasina
Convergent biomimetic semisynthesis of disesquiterpenoid rumphellolide J. Organic & biomolecular chemistry 20 (12) (2022)
Raitis Bobrovs, Emils Edgars Basens, Laura Drunka, Iveta Kanepe, Sofija Matisone, Karlis Kristofers Velins, Victor Andrianov, Gundars Leitis, Diana Zelencova-Gopejenko, Dace Rasina, Aigars Jirgensons, Kristaps Jaudzems
Exploring Aspartic Protease Inhibitor Binding to Design Selective Antimalarials. Journal of chemical information and modeling 62 (13) (2022)
Vitalii V Solomin, Alberts Seins, Aigars Jirgensons
Synthesis of indazoles from 2-formylphenylboronic acids. RSC advances 11 (37) (2021)
Olga Bobileva, Raitis Bobrovs, Iveta Kaņepe, Liene Patetko, Gints Kalniņš, Mihails Šišovs, Anna L Bula, Solveiga Gri Nberga, Ma Rtiņš Borodušķis, Anna Ramata-Stunda, Nils Rostoks, Aigars Jirgensons, Kaspars Tars, Kristaps Jaudzems
Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate. ACS medicinal chemistry letters 12 (7) (2021)
Elina Lidumniece, Chrislaine Withers-Martinez, Fiona Hackett, Christine R Collins, Abigail J Perrin, Konstantinos Koussis, Claudine Bisson, Michael J Blackman, Aigars Jirgensons
Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1. Proceedings of the National Academy of Sciences of the United States of America 118 (20) (2021)
Georgijs Stakanovs, Anatoly Mishnev, Dace Rasina, Aigars Jirgensons
A Concise Bioinspired Semisynthesis of Rumphellaones A-C and Their C-8 Epimers from β-Caryophyllene. Journal of natural products 83 (6) (2020)
Marija Skvorcova, Lukass T Lukasevics, Aigars Jirgensons
Amination of Carbenium Ions Generated by Directed Protonolysis of Cyclopropane. The Journal of organic chemistry 84 (7) (2019)
Raitis Bobrovs, Kristaps Jaudzems, Aigars Jirgensons
Exploiting Structural Dynamics To Design Open-Flap Inhibitors of Malarial Aspartic Proteases. Journal of medicinal chemistry 62 (20) (2019)
Linda Kinena, Gundars Leitis, Iveta Kanepe-Lapsa, Raitis Bobrovs, Kristaps Jaudzems, Vita Ozola, Edgars Suna, Aigars Jirgensons
Azole-based non-peptidomimetic plasmepsin inhibitors. Archiv der Pharmazie 351 (9) (2018)
Marija Skvorcova, Aigars Jirgensons
Amide-Group-Directed Protonolysis of Cyclopropane: An Approach to 2,2-Disubstituted Pyrrolidines. Organic letters 19 (10) (2017)