The Notch pathway attenuates burn-induced acute lung injury in rats by repressing reactive oxygen species.

Weixia CaiKuo ShenPeng JiYanhui JiaShichao HanWanfu ZhangXiaolong HuXuekang YangJuntao HanDahai Hu

Published in: Burns & trauma (2022)

The Notch pathway reduced ROS production and apoptosis by downregulating the expression of NOX4 in burn-stimulated PMVECs. The Notch-NOX4 pathway may be a novel therapeutic target to treat burn-induced ALI.

Keyphrases

reactive oxygen species
high glucose
cell proliferation
cell death
poor prognosis
wound healing
oxidative stress
dna damage
endoplasmic reticulum stress
lipopolysaccharide induced
lps induced
inflammatory response
long non coding rna
signaling pathway