Simiao Pill Attenuates Collagen-Induced Arthritis in Rats through Suppressing the ATX-LPA and MAPK Signalling Pathways.
Pan ShenSheng-Hao TuHui WangKai QinZhe ChenPublished in: Evidence-based complementary and alternative medicine : eCAM (2019)
The antirheumatic effects of SM were associated with the regulation of the ATX-LPA and MAPK pathways, the suppression of proinflammatory cytokine production, and the alleviation of cartilage and bone injury. These findings suggest that SM might be a promising alternative candidate for RA therapy.
Keyphrases
- rheumatoid arthritis
- signaling pathway
- pi k akt
- oxidative stress
- diabetic rats
- disease activity
- high glucose
- bone mineral density
- rheumatoid arthritis patients
- ankylosing spondylitis
- extracellular matrix
- drug induced
- soft tissue
- interstitial lung disease
- stem cells
- systemic lupus erythematosus
- postmenopausal women
- bone regeneration
- cell proliferation
- body composition
- endothelial cells
- tissue engineering
- replacement therapy