Acinetobacter baumannii: Pathogenesis, virulence factors, novel therapeutic options and mechanisms of resistance to antimicrobial agents with emphasis on tigecycline.
Razieh DehbanipourZohreh GhalavandPublished in: Journal of clinical pharmacy and therapeutics (2022)
In the present review we highlight microbiological and virulence traits in A. baumannii and peruse the tigecycline resistance mechanisms and novel therapeutic options. Among the novel therapeutic strategies we focus on combination therapy, drug repurposing, novel antibiotics, bacteriophage therapy, antimicrobial peptides (AMPs), human monoclonal antibodies (Hu-mAbs), nanoparticles and gene editing.
Keyphrases
- acinetobacter baumannii
- pseudomonas aeruginosa
- combination therapy
- staphylococcus aureus
- multidrug resistant
- drug resistant
- biofilm formation
- cystic fibrosis
- escherichia coli
- endothelial cells
- antimicrobial resistance
- genome wide
- induced pluripotent stem cells
- emergency department
- stem cells
- pluripotent stem cells
- drug induced
- bone marrow