Effects of Chemotherapy and Radiotherapy on Spermatogenesis: The Role of Testicular Immunology.
Ning QuMasahiro ItohKou SakabePublished in: International journal of molecular sciences (2019)
Substantial improvements in cancer treatment have resulted in longer survival and increased quality of life in cancer survivors with minimized long-term toxicity. However, infertility and gonadal dysfunction continue to be recognized as adverse effects of anticancer therapy. In particular, alkylating agents and irradiation induce testicular damage that results in prolonged azoospermia. Although damage to and recovery of spermatogenesis after cancer treatment have been extensively studied, there is little information regarding the role of differences in testicular immunology in cancer treatment-induced male infertility. In this review, we briefly summarize available rodent and human data on immunological differences in chemotherapy or radiotherapy.
Keyphrases
- locally advanced
- oxidative stress
- germ cell
- rectal cancer
- early stage
- diabetic rats
- endothelial cells
- radiation therapy
- squamous cell carcinoma
- radiation induced
- high glucose
- polycystic ovary syndrome
- electronic health record
- young adults
- multidrug resistant
- induced pluripotent stem cells
- big data
- type diabetes
- emergency department
- pluripotent stem cells
- metabolic syndrome
- insulin resistance
- social media
- mesenchymal stem cells
- skeletal muscle
- adipose tissue
- stress induced
- replacement therapy
- oxide nanoparticles