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The influence of congenital corneal opacity on ERGs obtained using an abbreviated protocol.

Alkiviades LiasisElena FrancoAmgad EldibSian HandleyHannah L ScangaKen K Nischal
Published in: Ophthalmic genetics (2022)
Selective reduction of the scotopic bright flash ERG b-wave is typically caused by retinal dysfunction that is post-phototransduction or inner retinal. In infants with CCO, scotopic ERGs to bright flashes can show a reduced b:a ratio that improves or normalizes either after PK or stimulus intensity reduction. The study highlights that media opacity can contribute to the generation of an ERG with reduced b-wave in the absence of inner retinal dysfunction.
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